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Louisville opens as a 22-point underdog vs. Clemson

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The Tigers remain the only Atlantic Division opponent Louisville has yet to defeat.

Louisville v Clemson Photo by Streeter Lecka/Getty Images

Louisville opened as a 22-point underdog for this Saturday’s game against unbeaten and third-ranked Clemson. The early money appears to be coming in on the reigning national champions, because the line has quickly moved to Clemson -23.

For comparison’s sake, U of L was a massive 39.5-point underdog when they visited Death Valley last November. That number proved to be not nearly enough, as the Cardinals returned home after being handed a 77-16 whoopin’.

After covering the spread a nation-low one time in 2018, Louisville is 4-2 ATS heading into its seventh game.

The Cards and Tigers will kick off at noon inside Cardinal Stadium this Saturday. ABC has the television coverage.