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Louisville is an 11.5-point underdog at Duke

The Cards have their work cut out for them in Cameron.

NCAA Basketball: Virginia at Duke Rob Kinnan-USA TODAY Sports

On the heels of a 17-point home loss to North Carolina, Louisville will be an 11.5-point underdog when it takes the court against No. 5 Duke Wednesday night in Durham.

Earlier this season, Louisville was a 10-point underdog when it faced Virginia in Charlottesville. That was the first time the Cardinals had been a double-digit underdog since being a 14.5-point dog against Connecticut on March 4, 2006. UConn wound up winning that game, 84-80.

U of L hasn’t won a game as a double-digit underdog since Jan. 24, 2001 when it beat Cincinnati 63-54 despite being a 14-point underdog. Since then, the Cardinal have lost nine straight games when being a double-digit underdog.

Ken Pomeroy currently projects Duke to win the game by a final score of 87-75.