According to fbschedules.com, the University of Louisville Cardinals will take on the Ole Miss Rebels in the Chick-fil-A Kickoff game in the year 2021. The game will be played in Atlanta, Georgia at the new Mercedez-Benz Stadium and be shown on either CBS or ABC/ESPN.
Louisville has played in this game once before, falling to Auburn 31-24 in 2015. The Cards and Rebels have never met on the gridiron.
We now know the opening opponent for Louisville for the next five seasons.
2017 - Purdue (Indianapolis, IN)
2018 - Alabama (Orlando, FL)
2019 - Notre Dame (home)
2020 - Murray State (home)
2021 - Ole Miss (Atlanta, GA)