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Louisville opens as a 12.5-point favorite over Houston

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Brett Davis-USA TODAY Sports

Despite opening the season with a neutral field loss to Auburn, Louisville will be a decisive favorite when it takes the field again on Saturday against the Houston Cougars. The opening line from Vegas has the Cards pegged as 12.5-point favorites in the game, which will kick off at noon.

In its first game under new head coach Tom Herman, Houston rolled to a 52-24 win over visiting Tennessee Tech last Saturday. Junior quarterback Greg Ward Jr. was the star of stars, throwing for 275 yards and a touchdown and rushing for 107 yards and two more scores. In all, the Cougar offense racked up 627 yards of total offense, 355 of that through the air. Herman became only the third head coach in school history to lead the Cougars to 50+ points in their inaugural games, joining Kevin Sumlin (W, 55-3, vs. Southern, Aug. 30, 2008) and Bill Meek (W, 54-12, vs. Montana, Sept. 17, 1955).

Louisville has not lost as a double-digit favorite since being upset by Central Florida at home back on Oct. 18, 2013. The Cards were favored to win that game by two touchdowns.

At the moment, there does appear to be a heavy chance of rain on Saturday, something which could affect the spread as the week goes on.