Northern Iowa is a 2.5-point favorite over Louisville

Despite being the better seed, Louisville will be an underdog when it takes the court against Northern Iowa in Seattle on Sunday night. The Panthers are currently a 2.5-point favorite at just about every sports book on the planet.

This will be the first time Louisville hasn't been favored to win a game in the NCAA Tournament since squaring off against No. 1 overall seed Kentucky in the 2012 Final Four.

This will be the sixth time this season that the Cards will go into a game as an underdog. Louisville is 1-4 in those games so far, with road losses to North Carolina and Virginia, a home loss to UK and a neutral site loss to UNC in the ACC Tournament. U of L won as a home underdog in the regular season finale against UVA.