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Louisville is a 9-point favorite over UC Irvine

Grant Halverson/Getty Images

Louisville opened as an 8.5-point favorite over 13th-seeded UC Irvine late Sunday night, a line which has since been bet up to the Cards -9.

History says that's a pretty good sign.

The lone loss, of course, was U of L's upset at the hands of Morehead State in 2011, another 4/13 matchup. The Cards were also 9-point favorites in that game.

In case you were wondering, here are the lines on the other 4/13 games:

Maryland by 5 over Valparaiso (Midwest)

North Carolina by 10 over Harvard (West)

Georgetown by 7.5 over Eastern Washington (South)