Indiana used a five-run seventh inning to knock off the Louisville baseball team 6-5 at Jim Patterson Stadium on Wednesday.
The Cards trounced the Hoosiers 16-3 in Bloomington Tuesday afternoon.
Louisville wasted great scoring opportunities in the first and second innings, a theme that would plague them for the rest of the day.
"On our side, when you look at it, you get 12 hits and six stolen bases and you only score five runs, we just didn't do enough to win," said head coach Dan McDonnell. "I feel responsible as the head coach and I'm sure our kids feel sick right now."
Louisville's Boomer Whiting and Jorge Castillo led the offense, eah turning in 3 for 3 days at the dish. Whiting also swiped three more bases, extending his single season record to 60, which is double the previous mark of 30.
The Cards now host Notre Dame in a big three-game weekend series, beginning with a doubleheader Saturday at Noon.