According to Jon Rothstein of CBS Sports, Luke Hancock will miss the first three games because of an achilles injury. Here is the story from cbs.com
The 6-6 Hancock was the Final Four's Most Outstanding Player last April and averaged 8.1 points per game last season.
Without Hancock and suspended forward Chane Behanan, Louisville will likely be without two of its top six rotation players for the first two weeks of the season.
Should Hancock return after the Cardinals' first three games, his first appearance of the 2013-14 season would be against Fairfield at the Hall of Fame tip-off tournament at Mohegan Sun on 11/23. If Louisville beats Fairfield, the Cardinals will play the winner of North Carolina/Richmond the next day."
Now with this being said, I don't think this hurts Louisville at all unless he misses more than those three games and we have to play a North Carolina team without him.