10. Louisville-West Virginia
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The rivalry wasn't born until the Cardinals joined the Big East before the 2005 season, but it has produced some of the best games of the past decade. In 2005, the outcome wasn't decided until the third overtime. After freshman West Virginia tailback Steve Slaton scored his sixth touchdown of the game and quarterback Pat White added a two-point conversion pass, Cardinals quarterback Brian Brohm was tackled short of the end zone on a two-point run, giving the Mountaineers a 46-44 victory. The next season, Louisville took advantage of West Virginia's three turnovers to win 44-34. In 2007, White scored on a 50-yard run with 1:36 left to give the Mountaineers a 38-31 victory.

Edited to reflect modern era.